Fourteen doctors at nine Marie Stopes International Centres in Victoria, NSW, the ACT, Queensland and Western Australia will offer the drug, also known as mifepristone, as an alternative to surgical abortions.
The Therapeutic Goods Administration will allow the drug's use of up to nine week's gestation under relaxed importing and prescribing rules, Fairfax reports.
Many prescribers of RU486 work in hospitals under limited circumstances.
Staff at Melbourne's Royal Women's Hospital can prescribe the drug only if a patient proves a specific need for a non-surgical abortion, but staff at MSI can prescribe it if a woman chooses it.